NOVATACH™ Peptide-coupled Alginates
NOVATACH™ peptide-coupled alginates are designed to facilitate and promote interactions between cells and alginate-based scaffolds or matrices. NOVATACH™ peptide-coupled alginates are particularly useful when cell-to-matrix interactions are beneficial and for cell immobilization.
Chemistry
Properties
Cell interaction with biomaterials is mediated through trans-membrane receptors that recognize adhesion molecules at material surfaces. The RGD peptide sequence is a most common example of such adhesion ligand. It has been shown that NOVATACH™ MVG GRGDSP successfully initiates biological interactions between alginate hydrogels and cells [1].
[1] J.E. Melvik, M. Dornish, Alginate as a carrier for cell immobilisation, Book Chapter: Fundamentals of cell Immobilisation Biotechnology (2004), ISBN 1-4020-1887-8, 33-51.
NOVATACH™ improves cells and tissue growth - NOVATACH™ MVG GRGDSP
Data: E. Alsberg, K.W. Anderson, A. Albeiruti, J.A. Rowley, D.J. Mooney, Engineering growing tissues, PNAS 99 (2002), 12025-12030.
RGD-alginate NOVATACH™ improves in-vivo cartilage formation in mice. Bovine Articular Chondrocytes (BAC) grown in alginate gives an inhomogeneous and loose structure (left). BAC grown in RGD-alginate gives a homogeneous and firm structure (middle) and display significantly higher growth rate than BAC in alginate alone (left).
Safety and toxicology
Recent data was generated that show the safety of NOVATACH™ peptide-coupled alginates. We can provide this information upon request using our contact page.
Applications
- Encapsulation of living cells and therapeutic proteins for cell therapy and advanced drug delivery
- 3D bioprinting
- Foams and cell tissue scaffolds
- Cell culture
- Hydrogels
- Implants
Product Selection
NOVATACH™ Peptide-coupled Alginates – NOVATACH™ Product Table
| Product name | G/M ratio | Availability | |
|---|---|---|---|
|
NOVATACH™ MVG GRGDSP |
≥1.5 |
|
|
|
NOVATACH™ VLVG 4GRGDSP |
≥1.5 |
Conditional |
|
|
NOVATACH™ LVM GRGDSP |
≤ 1 |
Conditional |
|
|
NOVATACH™ G VAPG |
≥1.5 |
Conditional |
|
|
NOVATACH™ M REDV |
≤ 1 |
Conditional |
Please note that we can manufacture specific tailor-made NOVATACH™ peptide-coupled alginates products with different specifications.
If you require additional information, please connect with us using our Contact page.
