- Viscosity [mPa*s] : < 20
- Appr. Mw [kDa] : < 75
- G/M Ratio : ≤ 1
- Endotoxins [EU/g] : ≤ 100
- Total viable count [cfu/g] : ≤ 100
PRONOVA® UltraPure or Sterile Sodium Alginates

NovaMatrix® is the world’s leading producer of medical grade Sodium Alginates: we have been manufacturing UltraPure Alginates since 1988. PRONOVA® UltraPure and PRONOVA® Sterile sodium alginates are our flagship products.
PRONOVA® alginates, a solid track record of safety and efficacy –
PRONOVA® alginates are very versatile, well-characterized, safe and bio-compatible marine biopolymers. They have been purified for biomedical and pharmaceutical applications. PRONOVA® UltraPure Alginates have been used in commercial medical applications for over two decades.

Chemistry
Alginate is a naturally-occurring biopolymer extracted from brown seaweed.
Alginate is a linear biopolymer with homopolymeric blocks of (1-4)-linked β-D-mannuronate (M) and α-L-guluronate (G) residues, respectively, covalently linked together in different sequences or blocks. The monomers can appear either as homopolymeric blocks of consecutive G-residues (G-blocks), consecutive M-residues (M-blocks), alternating M and G-residues (MG-blocks), or randomly organized sequences. The relative amount of each block type is a parameter we control since it influences the alginate’s properties and functionality.
In contrast to most other polysaccharides, Alginates can form hydrogels at constant temperature, in presence of divalent cations such as Ca2+, Ba2+ or Sr2+. This unique property is particularly useful in applications involving fragile materials like cells or tissue with low tolerance for higher temperatures. For more information, please click on the hyperlink PRONOVA® Alginates – Hydrogels formation and fill in a simple contact form.
Properties
- Form 3-dimentional hydrogel matrixes in presence of divalent cations
• Ability to form beads to entrap cells and therapeutic actives
• Ability to form 3D scaffolds, foams and other structures - Cell affinity
• Cell entrapment in alginate matrixes
• Controlled viscosity and gelation based on alginate type and cation selection Wide range of viscosities and gel strengths available - Cold / hot water solubility
- Rheology modification
- Suspending agent
- Film forming
- Naturally-occurring biopolymer with 20+ years in commercial applications
• Safe, biocompatible - Ultrapure, for medical use
- Long shelf-life: from 3 to 5 years, depending on the product

Safety and toxicology
The safety and toxicology profile of PRONOVA® UltraPure sodium alginate is described in a Drug Master File (DMF) submitted to the US FDA. If you would like to learn more about the Safety and toxicology of PRONOVA® UltraPure Alginates, please click on the hyperlink and fill in a simple contact form.
Applications

- Encapsulation of living cells and therapeutic proteins for cell therapy and advanced drug delivery
- Bone putty binder for tissue engineering and reconstruction
- Cryoprotection for cell and tissue
- 3D bioprinting
- Foams and cell tissue scaffolds
- Cell culture
- Hydrogels
- Advanced drug delivery
- Implants
- Anti-adhesion
- Wound management
- Medical device coating, etc.
Product selection
PRONOVA® UltraPure Alginates – PRONOVA® UP Product Table

All our PRONOVA® UltraPure Alginates have ≤ 100 EU / g endotoxins specifications as well as ≤ 100 cfu /g total viable count specifications.
We have the ability to supply PRONOVA® UltraPure Alginates at lower endotoxins specifications, as well as tailor-made grades. Please connect with us for more information.
The shelf-life of PRONOVA® UltraPure Alginates varies by grade. If you would like to learn more about PRONOVA® Alginates product shelf-life, please click on the hyperlink and fill in a simple contact form.
PRONOVA® Sterile Alginates – PRONOVA® S Product Table
All our PRONOVA® Sterile Alginates have ≤ 100 EU / g endotoxins specifications.
We have the ability to supply PRONOVA® Sterile Alginates at lower endotoxins specifications, as well as tailor-made grades. Please connect with us for more information.
The shelf-life of PRONOVA® Sterile Alginates varies by grade. If you would like to learn more about PRONOVA® Alginates product shelf-life, please click on the hyperlink and fill in a simple contact form.

Alginate is a linear polysaccharide consisting of (1,4)-linked b-D-mannuronate (M) and its C-5 epimer α-L-guluronate (G).
The monomers can appear in homopolymeric blocks of consecutive G-residues (G-blocks), consecutive M-residues (M-blocks), alternating M and G-residues (MG-blocks) or randomly organized blocks.
PRONOVA UP VLVM
PRONOVA UP LVM
- Viscosity [mPa*s] : 20-200
- Appr. Mw [kDa] : 75-200
- G/M Ratio : ≤ 1
- Endotoxins [EU/g] : ≤ 100
- Total viable count [cfu/g] : ≤ 100
PRONOVA UP MVM
- Viscosity [mPa*s] > 200
- Appr. Mw [kDa] : > 200
- G/M Ratio : ≤ 1
- Endotoxins [EU/g] : ≤ 100
- Total viable count [cfu/g] : ≤ 100
PRONOVA UP VLVG
- Viscosity [mPa*s] : < 20
- Appr. Mw [kDa] : < 75
- G/M Ratio : ≥ 1.5
- Endotoxins [EU/g] : ≤ 100
- Total viable count [cfu/g] : ≤ 100
PRONOVA UP LVG
- Viscosity [mPa*s] : 20-200
- Appr. Mw [kDa] : 75-200
- G/M Ratio : ≥ 1.5
- Endotoxins [EU/g] : ≤ 100
- Total viable count [cfu/g] : ≤ 100
PRONOVA UP MVG
- Viscosity [mPa*s] : > 200
- Appr. Mw [kDa] : > 200
- G/M Ratio : ≥ 1.5
- Endotoxins [EU/g] : ≤ 100
- Total viable count [cfu/g] : ≤ 100
Product
Viscosity [mPa*s]
Appr. Mw [kDa]
G/M Ratio
Endotoxins [EU/g]
Total viable count [cfu/g]
PRONOVA SLM20
- Viscosity [mPa*s] : 20-99
- Appr. Mw [kDa] : 75-150
- G/M Ratio : ≤ 1
- Endotoxins [EU/g] : ≤ 100
- Total viable count [cfu/g] : Sterile
PRONOVA SLM100
- Viscosity [mPa*s] : 100-300
- Appr. Mw [kDa] : 150-250
- G/M Ratio : ≤ 1
- Endotoxins [EU/g] : ≤ 100
- Total viable count [cfu/g] : Sterile
PRONOVA SLG20
- Viscosity [mPa*s] : 20-99
- Appr. Mw [kDa] : 75-150
- G/M Ratio : ≥ 1.5
- Endotoxins [EU/g] : ≤ 100
- Total viable count [cfu/g] : Sterile
PRONOVA SLG100
- Viscosity [mPa*s] : 100-300
- Appr. Mw [kDa] : 150-250
- G/M Ratio : ≥ 1
- Endotoxins [EU/g] : ≤ 100
- Total viable count [cfu/g] : Sterile
Product
Viscosity [mPa*s]
Appr. Mw [kDa]
G/M Ratio
Endotoxins [EU/g]
Total viable count [cfu/g]
NOVATACH MVG GRGDSP (GRGDSP-coupled high G-content high Mw alginate)
- G/M Ratio : ≥ 1.5
NOVATACH VLVG 4GRGDSP (GRGDSP-coupled high G-content low Mw alginate)
- G/M Ratio : ≥ 1.5
NOVATACH LVM GRGDSP (GRGDSP-coupled alginate)
- G/M Ratio : ≤ 1
NOVATACH G VAPG (VAPG-coupled alginate)
- G/M Ratio : ≥ 1.5
NOVATACH M REDV (REDV-coupled alginate)
- G/M Ratio : ≤ 1